Aqueous humor microRNA profiling in primary congenital glaucoma
نویسندگان
چکیده
منابع مشابه
Hypophosphorylation of aqueous humor sCD44 and primary open-angle glaucoma.
PURPOSE The ectodomain of CD44, the principal receptor for hyaluronic acid (HA), is shed as a 32-kDa fragment-soluble CD44 (sCD44)-which is cytotoxic to trabecular meshwork (TM) cells and retinal ganglion cells (RGCs) in culture. The purpose of this study was to characterize sCD44 further by determining the phosphorylation of aqueous humor sCD44 in normal and primary open-angle glaucoma (POAG)....
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Background: Glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. In patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis. Objective: To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in ...
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PURPOSE Extracellular microRNAs (miRNAs) in aqueous humor were suggested to have a role in transcellular signaling and may serve as disease biomarkers. The authors adopted next-generation sequencing (NGS) techniques to further characterize the miRNA profile in single samples of 60 to 80 μL human aqueous humor. METHODS Samples were obtained at the outset of cataract surgery in nine independent...
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We read the paper written by Razeghinejad et al. (1), who conducted a study on anti- Helicobacter pylori (H. pylori) IgG antibody levels in an Iranian glaucoma cohort, with considerable interest and based on our original concept (2-5). The authors concluded that a relation between H. pylori infection and primary open-angle glaucoma is not supported by their results, because the aqueous anti- H....
متن کاملFree radicals in the aqueous humor of patients with glaucoma
PURPOSE To clarify the presence of oxidative stress in glaucoma and discuss whether free radicals contribute to neovascular glaucoma (NVG) and non-NVG. METHODS Two patient groups were formed: the NVG group (n = 10) and the non-NVG group (n = 17). Free radicals in aqueous humor were detected by measuring the electron spin resonance (ESR). To identify free radical species, either superoxide dis...
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ژورنال
عنوان ژورنال: Journal of Translational Science
سال: 2016
ISSN: 2059-268X
DOI: 10.15761/jts.1000169